We are thrilled to share the latest paper of our mathematical modeler, Csaba Katai, on the neonatal Fc receptor (FcRn) regulated clearance mechanism for antibodies. The work not only contributes to the larger physiology-based pharmacokinetic models published in the literature but also provides a simple expression for clearance (and AUC) in terms of the model parameters, which has significant practical implications.
The analysis highlights that for dose levels typically used in the clinic, this clearance mechanism is effectively linear, whereas for doses sufficiently high, such as those used in IVIG therapy, clearance is nonlinear. Furthermore, the conclusions that may be drawn from the simple expression for clearance have been shown to manifest in our in-house whole-body PBPK model (see poster 11153 presented at PAGE2024).
We’d like to thank our collaborators and contributors, as well as the reviewers for their work in publishing this paper.
Are you interested in this remarkable paper on the FcRn mechanismor the corresponding PAGE2024 poster? Let us know in the comments, and we’ll send you a personal message with the link.
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